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2020). ACKR3 functions as a 'scavenger' that 'traps' the secreted opioids and helps prevent them from binding towards the classical receptors, therefore dampening their analgesic action and acting as being a regulator from the opioid process.

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These drugs, which mimic the function with the opioid peptides, may have major Negative effects when individuals acquire them frequently or in large amounts.

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